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Lipitor|
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Lipitor has been shown in clinical studies to produce reductions in LDL-cholesterol in patients with elevated cholesterol of 39 percent to 60 percent across the dose range of 10 to 80 mg. Furthermore, in clinical trials with Lipitor (10 to 80 mg) in patients with hypertriglyceridemia show further reductions of triglycerides by 25 to 56 percent. Reductions in triglycerides of 19 percent to 37 percent were reported in clinical trials in patients with mild to moderate hypercholesterolemia across the same dose range.
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Do not take Lipitor without first talking to your doctor if you have liver disease.
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Alcohol and Lipitor can both damage your liver. Discuss with your doctor the amount of alcohol that you drink so that it can be determined if Lipitor is the best choice for lowering your cholesterol.
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Do not take Lipitor if you are pregnant, if you are planning a pregnancy, or if you are breast-feeding a baby.
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Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if it is accompanied by a fever or flulike symptoms or yellowing of your skin or eyes.
The recommended starting dose of Lipitor is 10mg once daily. The dosage range is 10 to 80 mg once daily.
Lipitor is generally well tolerated. Adverse reactions are similar to other statins and have usually been mild and transient, with fewer than two percent of patients being discontinued from clinical trials due to side effects related to Lipitor. This rate of discontinuation was comparable to that of placebo. Myopathy should be considered in any patient with diffuse myalgias, muscle tenderness or weakness, and/or marked elevation of creatine phosphokinase, which may be more frequent when co-administered with drugs that inhibit the cytochrome P-450 metabolising enzyme system. The most frequent adverse events of atorvastatin reported during clinical trials are constipation, flatulence and dyspepsia. It is recommended that liver functions tests be performed prior to initiating therapy and periodically thereafter.
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Lipitor
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